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. 2012 Mar;50(3):1023-6.
doi: 10.1128/JCM.06248-11. Epub 2011 Dec 14.

Detection of favorable oral cephalosporin-clavulanate interactions by in vitro disk approximation susceptibility testing of extended-spectrum-Beta-lactamase-producing members of the enterobacteriaceae

Jennifer D Campbell  1 , James S Lewis 2nd, M Leticia McElmeel, Letitia C Fulcher, James H Jorgensen
Affiliations

Detection of favorable oral cephalosporin-clavulanate interactions by in vitro disk approximation susceptibility testing of extended-spectrum-Beta-lactamase-producing members of the enterobacteriaceae

Jennifer D Campbell et al. J Clin Microbiol. 2012 Mar.

Abstract

Extended-spectrum-beta-lactamase (ESBL)-producing members of the Enterobacteriaceae are often resistant to multiple drug classes, making therapy of urinary infections with oral antibiotics difficult. Previously it was shown that amoxicillin-clavulanate can provide clavulanate inhibition of ESBLs and protect an oral cephalosporin present in combination when tested by broth microdilution. This study has shown that disk approximation testing could detect favorable cephalosporin-clavulanate interactions among a group of 101 previously characterized members of the Enterobacteriaceae with CTX-M, SHV, or TEM ESBLs.

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Figures

Fig 1
Fig 1
Example of potentiation definitions between both cefdinir (CDR) and cefpodoxime (CPD) with amoxicillin-clavulanate (AMC) by disk approximation testing. Amoxicillin-clavulanate disks were placed 15 mm from the cefdinir and cefpodoxime disks. (a and b) Positive potentiation; (c) partial potentiation; (d) no potentiation.
See this image and copyright information in PMC

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References

    1. Cantón R, Coque TM. 2006. The CTX-M beta-lactamase pandemic. Curr. Opin. Microbiol. 9:466–475 - PubMed
    1. Clinical and Laboratory Standards Institute 2009. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 8th ed Approved standard M07–A8. CLSI, Wayne, PA
    1. Clinical and Laboratory Standards Institute 2011. Performance standards for antimicrobial susceptibility testing; 21st informational supplement. CLSI M100–S21 CLSI, Wayne, PA
    1. Lewis JS, II, Herrera M, Wickes B, Patterson JE, Jorgensen JH. 2007. First report of the emergence of CTX-M-type extended-spectrum beta-lactamases (ESBLs) as the predominant ESBL isolated in a U.S. health care system. Antimicrob. Agents Chemother. 51:4015–4021 - PMC - PubMed
    1. Miller LA, Ratnam K, Payne DJ. 2001. Beta-lactamase-inhibitor combinations in the 21st century: current agents and new developments. Curr. Opin. Pharmacol. 1:451–458 - PubMed

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