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. 2011 Apr;2(2):104-9.
doi: 10.4103/2231-4040.82956.

Antibacterial and antifungal activities from leaf extracts of Cassia fistula l.: An ethnomedicinal plant

Nayan R Bhalodia  1 , V J Shukla
Affiliations

Antibacterial and antifungal activities from leaf extracts of Cassia fistula l.: An ethnomedicinal plant

Nayan R Bhalodia et al. J Adv Pharm Technol Res. 2011 Apr.

Abstract

This study was carried out with an objective to investigate the antibacterial and antifungal potentials of leaves of Cassia fistula Linn. The aim of the study is to assess the antimicrobial activity and to determine the zone of inhibition of extracts on some bacterial and fungal strains. In the present study, the microbial activity of hydroalcohol extracts of leaves of Cassia fistula Linn. (an ethnomedicinal plant) was evaluated for potential antimicrobial activity against medically important bacterial and fungal strains. The antimicrobial activity was determined in the extracts using agar disc diffusion method. The antibacterial and antifungal activities of extracts (5, 25, 50, 100, 250 μg/ml) of Cassia fistula were tested against two Gram-positive-Staphylococcus aureus, Streptococcus pyogenes; two Gram-negative-Escherichia coli, Pseudomonas aeruginosa human pathogenic bacteria; and three fungal strains-Aspergillus niger, Aspergillus clavatus, Candida albicans. Zone of inhibition of extracts were compared with that of different standards like ampicillin, ciprofloxacin, norfloxacin, and chloramphenicol for antibacterial activity and nystatin and griseofulvin for antifungal activity. The results showed that the remarkable inhibition of the bacterial growth was shown against the tested organisms. The phytochemical analyses of the plants were carried out. The microbial activity of the Cassia fistula was due to the presence of various secondary metabolites. Hence, these plants can be used to discover bioactive natural products that may serve as leads in the development of new pharmaceuticals research activities.

Keywords: Cassia fistula; antifungal activity; in vitro antibacterial activity; secondary metabolites.

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Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Antibacterial activity against S. pyogenes (MTCC 442)
Figure 2
Figure 2
Antibacterial activity against S. aureus (MTCC 96)
Figure 3
Figure 3
Antibacterial activity against E. coli(MTCC 443)
Figure 4
Figure 4
Antibacterial activity against P. aeruginosa (MTCC 424)
Figure 5
Figure 5
Antifungal activity against A. niger (MTCC 282)
Figure 6
Figure 6
Antifungal activity against A. clavatus (MTCC 1323)
Figure 7
Figure 7
Antifungal activity against C. albicans (MTCC 227); CML - Hydroalcoholic extract of leaves
See this image and copyright information in PMC

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