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. 2011 Sep-Oct;56(5):37-40.

[Antiherpesviral activity of acycloguanosine H-phosphonate in experiments using laboratory animals]

[Article in Russian]
V L Andronova, G A Galegov, M V Ias'ko, M K Kukhanova, S N Kochetkov, Iu S Skoblov
  • PMID: 22171477

[Antiherpesviral activity of acycloguanosine H-phosphonate in experiments using laboratory animals]

[Article in Russian]
V L Andronova et al. Vopr Virusol. 2011 Sep-Oct.

Abstract

A study of the antiherpesviral activity of acycloguanosine (ACG) H-phosphonate (ACG-P) on a model of fatal herpesvirus infection in inbred BALB/c albino mice has established that ACG-P reduces death rates in the animals, considerably increases their average lifespan, and significantly decreases brain virus titers with both 60% mortality in the control and 92% mortality in the control group. There was also a significant inhibition of herpes simplex virus type 1 (HSV-1) replication in the brain tissue of animals receiving ACG-P on a model of ACG-resistant HSV-1/L2/RACG(TK-).

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