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Review
. 2012 Apr;19(3):215-23.
doi: 10.1111/j.1549-8719.2011.00154.x.

miR-210: the master hypoxamir

Yuk C Chan  1 , Jaideep Banerjee, Sang Yong Choi, Chandan K Sen
Affiliations
Review

miR-210: the master hypoxamir

Yuk C Chan et al. Microcirculation. 2012 Apr.

Abstract

MicroRNAs are small non-coding RNAs implicated mainly in post-transcriptional gene silencing by interacting with the untranslated region of the transcript. miR-210 represents major hypoxia-inducible miRs, also known as hypoxamirs, which is ubiquitously expressed in a wide range of cells, serving versatile functions. This review article summarizes the current progress on biogenesis of miR-210 and its physiological roles including arrest of cell proliferation, repression of mitochondrial respiration, arrest of DNA repair, vascular biology, and angiogenesis. Given the fact that miR-210 is aberrantly expressed in a number of diseases such as tumor progression, myocardial infarction and cutaneous ischemic wounds, miR-210 could serve as an excellent candidate for prognostic purposes and therapeutic intervention. With the advancement of computational prediction, high-throughput target validation methodology, sequencing, proteomic analysis, and microarray, it is anticipated that more down-stream targets of miR-210 and its associated biological consequences under hypoxia will be unveiled establishing miR-210 as a major hub in the biology of hypoxia-response.

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Figures

Figure 1
Figure 1
Summary of miR-210 targets and their biological consequences under hypoxia
Figure 2
Figure 2
miR-210 serves as prognostic and therapeutic targets
See this image and copyright information in PMC

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