"Ring-fencing" BRCA1 tumor suppressor activity
- PMID: 22172717
- DOI: 10.1016/j.ccr.2011.11.019
"Ring-fencing" BRCA1 tumor suppressor activity
Abstract
BRCA1 is a crucial human breast and ovarian cancer tumor suppressor gene. The article by Drost et al. in this issue of Cancer Cell together with a recent paper in Science now provide a clearer picture of how this large and complex protein suppresses tumorigenesis.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.Cancer Cell. 2011 Dec 13;20(6):797-809. doi: 10.1016/j.ccr.2011.11.014. Cancer Cell. 2011. PMID: 22172724
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