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Comment
. 2011 Dec 13;20(6):698-9.
doi: 10.1016/j.ccr.2011.11.021.

Targeting liver cancer: first steps toward a miRacle?

Robert F Schwabe  1 , Timothy C Wang
Affiliations
Comment

Targeting liver cancer: first steps toward a miRacle?

Robert F Schwabe et al. Cancer Cell. .

Abstract

In a recent issue of Cell, Iliopoulos and colleagues demonstrate a novel and targetable epigenetic amplification loop in hepatocellular carcinoma involving HNF4α, miR-124, IL6-R, Stat3, miR-24, and miR-629. These results establish microRNAs as novel players in early stages of hepatocarcinogenesis and as potential targets for the treatment of hepatocellular carcinoma.

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Figures

Figure 1
Figure 1. Transformation of hepatocytes by a HNF4α - miR-124 – IL6-R – Stat3 – miR-24/miR-629 amplification loop
Temporary suppression of HNF4α induces permanent suppression of HNF4α by a feed-forward amplification loop that includes decreased miR-124 expression after HNF4α suppression, a subsequent increase in IL-6R expression and Stat3 signaling, and an upregulation of Stat3-inducible and HNF4α-targeting microRNAs miR-24 and miR-629.
See this image and copyright information in PMC

Comment on

References

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