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. 2012 Apr;27(2):159-66.
doi: 10.1016/j.jcrc.2011.08.001. Epub 2011 Dec 14.

Incidence and risk factors for sepsis in surgical patients: a cohort study

Adriana Cristina Galbiati Parminondi Elias  1 , Tiemi Matsuo, Cintia Magalhães Carvalho Grion, Lucienne Tibery Queiroz Cardoso, Paulo Henrique Verri
Affiliations

Incidence and risk factors for sepsis in surgical patients: a cohort study

Adriana Cristina Galbiati Parminondi Elias et al. J Crit Care. 2012 Apr.

Abstract

Purpose: The aim of the study was to evaluate risk factors for infection and sepsis in surgical patients admitted to the intensive care unit (ICU).

Materials and methods: Data were prospectively collected from a cohort of surgical patients from January 2005 to December 2007. We analyzed the incidence of infection and sepsis and certain other variables from the pre-, intra-, and postoperative periods as risk factors for infection and sepsis.

Results: We studied 625 surgical patients. The mortality rate was 18.2%, and the mean age of the subjects was 53.1 ± 18.8 years. The incidences of severe sepsis and septic shock were 5% and 11.5%, respectively. A multivariate analysis showed that the following variables were associated with sepsis in the postoperative period: urgent surgery (odds ratio, 2.63; 95% confidence interval [CI], 1.50-4.63), fluid resuscitation (odds ratio, 1.90; 95% CI, 1.18-3.05), vasoactive drugs (odds ratio, 2.58; 95% CI, 1.61-4.14), and mechanical ventilation (odds ratio, 5.51; 95% CI, 3.07-9.89). A Sequential Organ Failure Assessment was associated with infection or sepsis upon ICU admission (area under the curve, 0.737 ± 0.019; 95% CI, 0.748-0.825).

Conclusions: This study showed that sepsis has high incidence and mortality in surgical patients admitted to the ICU. Urgent surgeries, mechanical ventilation, fluid resuscitation, and vasoactive drugs in the postoperative period and Sequential Organ Failure Assessment at ICU admission were risk factors for sepsis.

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