Gene expression in the Parkinson's disease brain

Abstract

The study of gene expression has undergone a transformation in the past decade as the benefits of the sequencing of the human genome have made themselves felt. Increasingly, genome wide approaches are being applied to the analysis of gene expression in human disease as a route to understanding the underlying pathogenic mechanisms. In this review, we will summarise current state of gene expression studies of the brain in Parkinson's disease, and examine how these techniques can be used to gain an insight into aetiology of this devastating disorder.

Fig. 1

From brain tissue to genomic analysis. The flow of information from brain samples through the purification process and the different systems that can be used to analyse gene expression.