Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis

Abstract

Purpose: The aim of this study was to investigate plasma and synovial fluid basic fibroblast growth factor (bFGF) levels in patients with primary knee osteoarthritis (OA) and to evaluate the correlation between bFGF levels and disease severity.

Methods: Thirty-five patients with knee OA and 15 healthy individuals were recruited into this study. Knee OA grading was performed according to the Kellgren-Lawrence classification. bFGF concentrations in both plasma and synovial fluid were determined using enzyme-linked immunosorbent assay.

Results: Plasma and synovial fluid bFGF levels in knee OA patients were significantly higher than in controls (P < 0.001). Moreover, plasma and synovial fluid bFGF concentrations were positively correlated with radiographic severity (r = 0.535, P < 0.001 and r = 0.570, P < 0.001, respectively). Further analysis revealed that there was a positive correlation between plasma and synovial fluid bFGF levels (r = 0.674, P < 0.001).

Conclusions: Plasma and synovial fluid bFGF levels were significantly increased in OA patients, and these elevated levels were positively correlated with radiographic severity. These findings indicate that bFGF levels may be a monitor of disease severity and could play an essential part in the pathophysiology of degenerative process in OA.

Fig. 1

Basic fibroblast growth factor (bFGF) levels in plasma and synovial fluid of patients with osteoarthritis (OA) (n = 35) and healthy controls (n = 15)

Fig. 2

Positive correlation between plasma basic fibroblast growth factor (bFGF) levels in patients with osteoarthritis (OA) and disease severity classified according to Kellgren and Lawrence (KL) grading scale (r = 0.535, P < 0.001)

Fig. 3

Positive correlation between synovial fluid (SF) basic fibroblast growth factor (bFGF) levels in patients with osteoarthritis (OA) and severity classified according to Kellgren and Lawrence (KL) grading scale (r = 0.570, P < 0.001)

Fig. 4

Positive correlation between plasma and synovial fluid (SF) basic fibroblast growth factor (bFGF) concentrations in patients with osteoarthritis (OA) (r = 0.674, P < 0.001)