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. 2012 Jan 26;55(2):914-23.
doi: 10.1021/jm2014748. Epub 2012 Jan 11.

Potent inhibitors of LpxC for the treatment of Gram-negative infections

Matthew F Brown  1 , Usa Reilly, Joseph A Abramite, Joel T Arcari, Robert Oliver, Rose A Barham, Ye Che, Jinshan Michael Chen, Elizabeth M Collantes, Seung Won Chung, Charlene Desbonnet, Jonathan Doty, Matthew Doroski, Juntyma J Engtrakul, Thomas M Harris, Michael Huband, John D Knafels, Karen L Leach, Shenping Liu, Anthony Marfat, Andrea Marra, Eric McElroy, Michael Melnick, Carol A Menard, Justin I Montgomery, Lisa Mullins, Mark C Noe, John O'Donnell, Joseph Penzien, Mark S Plummer, Loren M Price, Veerabahu Shanmugasundaram, Christy Thoma, Daniel P Uccello, Joseph S Warmus, Donn G Wishka
Affiliations

Potent inhibitors of LpxC for the treatment of Gram-negative infections

Matthew F Brown et al. J Med Chem. .

Abstract

In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid.

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