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. 2012 Jan 15;22(2):977-9.
doi: 10.1016/j.bmcl.2011.12.003. Epub 2011 Dec 8.

Synthesis and evaluation of 17α-E-20-(heteroaryl)norpregn-1,3,5(10),20 tetraene-3,17β-diols [17α-(heteroaryl)vinyl estradiols] as ligands for the estrogen receptor-α ligand binding domain (ERα-LBD)

Sandra L Olmsted  1 , Pakamas Tongcharoensirikul, Emmett McCaskill, Karla Gandiaga, David Labaree, Richard B Hochberg, Robert N Hanson
Affiliations

Synthesis and evaluation of 17α-E-20-(heteroaryl)norpregn-1,3,5(10),20 tetraene-3,17β-diols [17α-(heteroaryl)vinyl estradiols] as ligands for the estrogen receptor-α ligand binding domain (ERα-LBD)

Sandra L Olmsted et al. Bioorg Med Chem Lett. .

Abstract

A series of 17α-(heteroaryl)vinyl estradiols was prepared to evaluate the influence of heteroatom on the affinity and efficacy of estrogenic ligands for the estrogen receptor-alpha ligand binding domain (ERα-LBD). The products demonstrated reduced binding affinity compared to the parent 17α-E-phenyl vinyl estradiol, but the binding was relatively independent of the heteroatom. The greatest influence of the heteroatom was evident in the efficacy of the compounds as the thienyl derivatives 2f,g were more potent than either the pyridyl 2b-d or pyrimidinyl 2e analogs. The results suggest that a subtle interplay of interactions between the ligands and the receptor influences the biological response.

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Figures

Scheme 1
Scheme 1
Synthesis of (hetero)aryl vinyl estradiols 2a–g
See this image and copyright information in PMC

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