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Comparative Study
. 2012 Feb;33(2):112-23.
doi: 10.1097/DBP.0b013e318241ed23.

Language impairment in children perinatally infected with HIV compared to children who were HIV-exposed and uninfected

Mabel L Rice  1 , Ashley L Buchanan, George K Siberry, Kathleen M Malee, Bret Zeldow, Toni Frederick, Murli U Purswani, Howard J Hoffman, Patricia A Sirois, Renee Smith, Peter Torre 3rd, Susannah M Allison, Paige L Williams
Affiliations
Comparative Study

Language impairment in children perinatally infected with HIV compared to children who were HIV-exposed and uninfected

Mabel L Rice et al. J Dev Behav Pediatr. 2012 Feb.

Abstract

Objective: To investigate the risk for language impairment (LI) in children perinatally infected or exposed to HIV.

Methods: We evaluated the prevalence of LI in 7- to 16-year-old children with perinatal HIV infection (HIV+) compared with HIV-exposed and uninfected children, using a comprehensive standardized language test (Clinical Evaluation of Language Functioning-Fourth Edition [CELF-4]). LI was classified as primary LI (Pri-LI) (monolingual English exposure and no cognitive or hearing impairment), concurrent LI (Con-LI) (cognitive or hearing impairment), or no LI. Associations of demographic, caregiver, HIV disease, and antiretroviral treatment factors with LI category were evaluated using univariate and multivariable logistic regression models.

Results: Of the 468 children with language assessments, 184 (39%) had LI. No difference was observed by HIV infection status for overall LI or for Pri-LI or Con-LI; mean (SD) CELF-4 scores were 88.5 (18.4) for HIV+ versus 87.5 (17.9) for HIV-exposed and uninfected children. After adjustment, black children had higher odds of Pri-LI versus no LI (adjusted odds ratio [aOR] = 2.43, p = .03). Children who were black, Hispanic, had a caregiver with low education or low intelligence quotient, or a nonbiological parent as caregiver had higher odds of Con-LI versus no LI. Among HIV+ children, viral load >400 copies/mL (aOR = 3.04, p < .001), Centers for Disease Control and Prevention Class C (aOR = 2.19, p = .02), and antiretroviral treatment initiation <6 months of age (aOR = 2.12, p = .02) were associated with higher odds of Con-LI versus no LI.

Conclusions: Children perinatally exposed to HIV are at high risk for LI, but such risk was not increased for youth with HIV. Risk factors differed for Pri-LI and Con-LI.

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Figures

Figure 1
Figure 1
Percent with Certain Indicators of HIV Disease Severity among Perinatally HIV-infected Children within each Language Impairment Category, with 95% Confidence Intervals.
See this image and copyright information in PMC

References

    1. Blanchette N, Smith ML, King S, Fernandes-Penney A, Read S. Cognitive development in school-age children with vertically transmitted HIV infection. Dev. Neuropsychol. 2002;21(3):223–241. - PubMed
    1. Martin SC, Wolters PL, Toledo-Tamula MA, Zeichner SL, Hazra R, Civitello L. Cognitive functioning in school-aged children with vertically acquired HIV infection being treated with highly active antiretroviral therapy (HAART) Dev. Neuropsychol. 2006;30(2):633–657. - PubMed
    1. Brackis-Cott E, Kang E, Dolezal C, Abrams EJ, Mellins CA. The impact of perinatal HIV infection on older school-aged children's and adolescents' receptive language and word recognition skills. AIDS Patient Care STDS. 2009;23(6):415–421. - PMC - PubMed
    1. Brackis-Cott E, Kang E, Dolezal C, Abrams EJ, Mellins CA. Brief Report: Language ability and school functioning of youth perinatally infected with HIV. J. Pediatr. Health Care. 2009;23(3):158–164. - PMC - PubMed
    1. Coplan J, Contello KA, Cunningham CK, et al. Early language development in children exposed to or infected with Human Immunodeficiency Virus. Pediatrics. 1998;102(1):e8. - PubMed

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