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Review
. 2012 Jan 1;72(1):13-7.
doi: 10.1158/0008-5472.CAN-11-2196. Epub 2011 Dec 16.

Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage

Anup K Biswas  1 , David G Johnson
Affiliations
Review

Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage

Anup K Biswas et al. Cancer Res. .

Abstract

E2F is a family of transcription factors that regulate the expression of genes involved in a wide range of cellular processes, including cell-cycle progression, DNA replication, DNA repair, differentiation, and apoptosis. E2F1, the founding member of the family, undergoes posttranslational modifications in response to DNA damage, resulting in E2F1 stabilization. In some cases, E2F1 is important for DNA damage-induced apoptosis through the transcriptional activation of p73 and perhaps other proapoptotic target genes. However, in other contexts, E2F1 can stimulate DNA repair and promote survival in response to DNA damage. The E2F1 protein accumulates at sites of both DNA double-strand breaks and UV radiation-induced damage, indicating that E2F1 has a nontranscriptional function at sites of damage. This review summarizes recent progress made in understanding the role of E2F1 in the DNA damage response, including transcription-independent activities that facilitate DNA repair in the context of chromatin.

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Figures

Figure 1
Figure 1
A, DNA damage-inducible E2F1 posttranslational modifications. B, E2F1-containing complexes implicated in transcriptional regulation and DNA repair.
See this image and copyright information in PMC

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