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. 2012 Feb 13;19(1):C13-7.
doi: 10.1530/ERC-11-0309. Print 2012 Feb.

Should diabetic women with breast cancer have their own intervention studies?

David A Potter  1 , Douglas Yee, Zhijun Guo, Mariangellys Rodriguez
Affiliations

Should diabetic women with breast cancer have their own intervention studies?

David A Potter et al. Endocr Relat Cancer. .

Abstract

This commentary on 'Calorie restriction and rapamycin inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity' by Nogueira et al., published in this issue of Endocrine-Related Cancer, addresses the challenges of translating diet, exercise, and pharmacologic trials in diabetic mouse mammary tumor models to human studies. We propose that trials specifically designed to test such interventions in diabetic women with breast cancer would be valuable and informative.

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Conflict of interest statement

Declaration of interest

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

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References

    1. Abrahamson PE, Gammon MD, Lund MJ, Britton JA, Marshall SW, Flagg EW, Porter PL, Brinton LA, Eley JW, Coates RJ. Recreational physical activity and survival among young women with breast cancer. Cancer. 2006;107:1777–1785. - PubMed
    1. Arciero PJ, Vukovich MD, Holloszy JO, Racette SB, Kohrt WM. Comparison of short-term diet and exercise on insulin action in individuals with abnormal glucose tolerance. Journal of Applied Physiology. 1999;86:1930–1935. - PubMed
    1. Aston-Mourney K, Wong N, Kebede M, Zraika S, Balmer L, McMahon JM, Fam BC, Favaloro J, Proietto J, Morahan G, et al. Increased nicotinamide nucleotide trans-hydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes. Diabetologia. 2007;50:2476–2485. - PubMed
    1. Barone BB, Yeh HC, Snyder CF, Peairs KS, Stein KB, Derr RL, Wolff AC, Brancati FL. Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. Journal of the American Medical Association. 2008;300:2754–2764. - PMC - PubMed
    1. Berry DA, Cronin KA, Plevritis SK, Fryback DG, Clarke L, Zelen M, Mandelblatt JS, Yakovlev AY, Habbema JD, Feuer EJ. Effect of screening and adjuvant therapy on mortality from breast cancer. New England Journal of Medicine. 2005;353:1784–1792. - PubMed

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