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Comparative Study
. 2012 Mar;14(3):263-7.
doi: 10.1093/icvts/ivr085. Epub 2011 Dec 16.

Lung transplant for interstitial lung disease: outcomes for single versus bilateral lung transplantation

Nilto C De Oliveira  1 , Satoru Osaki, James Maloney, Richard D Cornwell, Keith C Meyer
Affiliations
Comparative Study

Lung transplant for interstitial lung disease: outcomes for single versus bilateral lung transplantation

Nilto C De Oliveira et al. Interact Cardiovasc Thorac Surg. 2012 Mar.

Abstract

This study was undertaken to evaluate outcomes for single (SLT) vs. bilateral lung transplantation (BLT) in patients with interstitial lung disease (ILD). One hundred and eleven patients with ILD who underwent lung transplantation between January 1993 and March 2009 were evaluated. Recipients with BLT were younger (43 ± 12 vs. 57 ± 7 years), and significantly more patients with non-idiopathic pulmonary fibrosis (IPF) received BLT (50%) vs. patients with IPF (18%). BLT recipients had a significantly longer mean waitlist time (240 vs. 125 days), significantly higher systolic (51 ± 18 vs. 40 ± 11 mmHg) pulmonary artery pressures, were placed on cardiopulmonary bypass more frequently (67 vs. 31%), had a higher incidence of primary graft dysfunction (63 vs. 17%), more frequently were given prolonged peri-operative inhaled nitric oxide and more frequently required prolonged post-operative mechanical ventilatory support (6.0 vs. 1.7 days). Additionally, BLT recipients had a significantly longer intensive care unit (8 vs. 4 days) and hospital (24 vs. 15 days) length of stay. We did not detect a difference in survival (Kaplan-Meier) for SLT vs. BLT. Our findings suggest that outcomes for SLT for patients with ILD are comparable or somewhat superior to those for BLT, and short- and long-term survival are not significantly different for the two procedures.

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Figures

Figure 1:
Figure 1:
Post-transplant survival after SLT and BLT for ILD by the Kaplan-Meier analysis. SLT, single lung transplant; BLT, bilateral lung transplant.
Figure 2:
Figure 2:
Per cent of predicted forced expiratory volume in 1 s after lung transplant for ILD. SLT, single lung transplant; BLT, bilateral lung transplant.
Figure 3:
Figure 3:
Freedom from BOS after SLT and BLT for ILD by the Kaplan-Meier analysis. SLT, single lung transplant; BLT, bilateral lung transplant.
Figure 4:
Figure 4:
Post-transplant survival after SLT and BLT for IPF by the Kaplan-Meier analysis. SLT, single lung transplant; BLT, bilateral lung transplant.
See this image and copyright information in PMC

References

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