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. 2011;4(2):104-106.
doi: 10.7156/v4i2p104.

The role of SIRT1 in tumorigenesis

Kai Li  1 , Jianyuan Luo
Affiliations

The role of SIRT1 in tumorigenesis

Kai Li et al. N Am J Med Sci (Boston). 2011.

Abstract

NAD-dependent Class III histone deacetylase SIRT1 is a multiple functional protein and has been demonstrated critically involved in stress response, cellular metabolism and aging through deacetylating variety of substrates including p53, forkhead transcription factors, PGC-1α, NF-κB, Ku70 and histones. Increasing evidences indicate that SIRT1 plays a complex role in tumorigenesis with functions in both tumor promoting and tumor suppressing. This review provides an overview of current knowledge of SIRT1 and its controversies regarding the functions of SIRT1 in tumorigenesis.

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