Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Apr;11(2):360-2.
doi: 10.1111/j.1474-9726.2011.00778.x. Epub 2012 Feb 1.

A neuroprotective role for the DNA damage checkpoint in tauopathy

Vikram Khurana  1 , Paola Merlo, Brian DuBoff, Tudor A Fulga, Katherine A Sharp, Shelagh D Campbell, Jürgen Götz, Mel B Feany
Affiliations
Free article

A neuroprotective role for the DNA damage checkpoint in tauopathy

Vikram Khurana et al. Aging Cell. 2012 Apr.
Free article

Abstract

ATM and p53, effectors of the DNA damage checkpoint, are generally considered pro-apoptotic in neurons. We show that DNA damage and checkpoint activation occurs in postmitotic neurons in animal models of tauopathy, neurodegenerative disorders that include Alzheimer's disease. Surprisingly, checkpoint attenuation potently increases neurodegeneration through aberrant cell cycle re-entry of postmitotic neurons. These data suggest an unexpected neuroprotective role for the DNA damage checkpoint in tauopathies.

PubMed Disclaimer

LinkOut - more resources