Invasive adenocarcinoma and related tumors of the uterine cervix

Abstract

Adenocarcinomas and related tumors now account for approximately 15% of carcinomas of the uterine cervix. In this review, the features of these neoplasms are reviewed with emphasis on their microscopic features, differential diagnosis, and subtypes about which there is new information such as adenoma malignum, and villoglandular, mesonephric, adenoid basal, and adenoid cystic carcinomas. These tumors may cause considerable diagnostic difficulty, sometimes being difficult to distinguish from nonneoplastic glandular proliferations. Their correct identification has major prognostic implications.