Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Mar-Apr;20(2):72-6.
doi: 10.1097/CRD.0b013e31823c808b.

Cardiac manifestations of neonatal lupus: a review of autoantibody-associated congenital heart block and its impact in an adult population

Christine Capone  1 , Jill P Buyon, Deborah M Friedman, William H Frishman
Affiliations
Review

Cardiac manifestations of neonatal lupus: a review of autoantibody-associated congenital heart block and its impact in an adult population

Christine Capone et al. Cardiol Rev. 2012 Mar-Apr.

Abstract

Within the last decade the prevalence of adult patients living with congenital heart disease equals that seen in children. This expanding population poses a challenge to clinical cardiologists who will be caring for patients with the clinical manifestations of this condition. Neonatal lupus is a model of passively acquired autoimmunity and is responsible for the majority of clinical cases of congenital heart block (CHB). This review will focus on the presentation, pathophysiology, and the long-term follow-up of CHB associated with neonatal lupus, and discuss important diagnostic tests, familial implications, and pacemaker issues associated with the care of an adult with CHB.

PubMed Disclaimer

References

    1. Marelli AJ, Mackie AS, Ionescu-Ittu R, et al. Congenital heart disease in the general population: changing prevalence and age distribution. Circulation. 2007;115:163–172. - PubMed
    1. Navaravong L, Cui J, Stoenescu M. A childhood illness…in an adult. Am J Med. 2010;123:907–909. - PubMed
    1. Dolara A, Cammelli D, Chiodi L, Favilli S. Acute cardiac failure following pacing in an adult patient with congenital complete heart block. J Cardiovasc Med. 2008;9:301–303. - PubMed
    1. Issa ZF, Miller JM, Zipes DP. Atrioventricular conduction abnormalities. In: Issa ZF, Miller JM, Zipes DP, editors. Clinical Arrhythmology and Electrophysiology. 1. Philadelphia: Saunders Elsevier; 2009. pp. 127–142.
    1. Balmer C, Fasnacht M, Rahn M, et al. Long-term follow up of children with congenital complete atrioventricular block and the impact of pacemaker therapy. Europace. 2002;4:345–349. - PubMed

Publication types

Supplementary concepts