Unusual location and function of the operator in the Escherichia coli galactose operon
- PMID: 221831
- DOI: 10.1038/279494a0
Unusual location and function of the operator in the Escherichia coli galactose operon
Abstract
The operator of the gal operon is located about 60 base pairs preceding the startpoints of the transcription of the two gal promoters. This location contrasts with the location of the operator in other phage or bacterial operons where the repressor binds more closely to the respective transcription initiation sites. Models explaining how the repressor-operator interactions may control the two gal promoters are presented.
Similar articles
-
Modulation of the two promoters of the galactose operon of Escherichia coli.Nature. 1979 Jun 7;279(5713):492-4. doi: 10.1038/279492a0. Nature. 1979. PMID: 221830
-
Studies with the Escherichia coli galactose operon regulatory region carrying a point mutation that simultaneously inactivates the two overlapping promoters. Interactions with RNA polymerase and the cyclic AMP receptor protein.FEBS Lett. 1987 Jul 13;219(1):189-96. doi: 10.1016/0014-5793(87)81214-0. FEBS Lett. 1987. PMID: 3297789
-
RNA polymerase and gal repressor bind simultaneously and with DNA bending to the control region of the Escherichia coli galactose operon.EMBO J. 1989 Apr;8(4):1247-55. doi: 10.1002/j.1460-2075.1989.tb03498.x. EMBO J. 1989. PMID: 2663472 Free PMC article.
-
Cyclic AMP receptor protein: role in transcription activation.Science. 1984 May 25;224(4651):831-8. doi: 10.1126/science.6372090. Science. 1984. PMID: 6372090 Review.
-
Mechanisms of glucocorticoid receptor function.Monogr Endocrinol. 1979;12:305-26. doi: 10.1007/978-3-642-81265-1_17. Monogr Endocrinol. 1979. PMID: 226871 Review. No abstract available.
Cited by
-
Tn10 tet operator mutations affecting Tet repressor recognition.Nucleic Acids Res. 1986 May 27;14(10):4253-66. doi: 10.1093/nar/14.10.4253. Nucleic Acids Res. 1986. PMID: 3086838 Free PMC article.
-
DNA sequence of the carA gene and the control region of carAB: tandem promoters, respectively controlled by arginine and the pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase in Escherichia coli K-12.Proc Natl Acad Sci U S A. 1984 Jul;81(13):4134-8. doi: 10.1073/pnas.81.13.4134. Proc Natl Acad Sci U S A. 1984. PMID: 6330744 Free PMC article.
-
Characterization of two mutations in the Escherichia coli galE gene inactivating the second galactose operator and comparative studies of repressor binding.EMBO J. 1983;2(12):2129-35. doi: 10.1002/j.1460-2075.1983.tb01713.x. EMBO J. 1983. PMID: 6365532 Free PMC article.
-
Unusual properties of promoter-up mutations in the Escherichia coli galactose operon and evidence suggesting RNA polymerase-induced DNA bending.EMBO J. 1987 Feb;6(2):507-13. doi: 10.1002/j.1460-2075.1987.tb04782.x. EMBO J. 1987. PMID: 3034593 Free PMC article.
-
Homologies between different procaryotic DNA-binding regulatory proteins and between their sites of action.EMBO J. 1982;1(5):591-5. doi: 10.1002/j.1460-2075.1982.tb01213.x. EMBO J. 1982. PMID: 6234163 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources