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Review
. 2012:723:519-25.
doi: 10.1007/978-1-4614-0631-0_65.

Transcriptome analyses to investigate the pathogenesis of RNA splicing factor retinitis pigmentosa

Michael H Farkas  1 , Greg R Grant, Eric A Pierce
Affiliations
Review

Transcriptome analyses to investigate the pathogenesis of RNA splicing factor retinitis pigmentosa

Michael H Farkas et al. Adv Exp Med Biol. 2012.
No abstract available

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Figures

Fig. 65.1
Fig. 65.1
Electron microscopy of representative retina and RPE from 2-year-old homozygous Prpf3-T494M, Prpf8-H2309P, and heterozygous 1-year-old Prpf31 knockout mice. (a) Representative wild-type control image for all three mouse models. (b) Representative image for all three mouse models showing vacuoles in the RPE. In the Prpf3-T494M and Prpf8-H2309P mice, loss of basal infoldings and accumulation of amorphous material between Bruch’s membrane and the RPE is evident (arrow). These changes are not evident in the control samples. Scale bars: (a, b) 2 μm; inset scale bars 0.2 μm. OS outer segments; RPE retinal pigment epithelium
See this image and copyright information in PMC

References

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