Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Jan 13;3(1):e2.
doi: 10.4081/hr.2011.e2. Epub 2011 Jan 21.

Severe isoniazid related sideroblastic anemia

Rein Jan Piso  1 , Kveti Kriz, Marie-Claire Desax
Affiliations
Case Reports

Severe isoniazid related sideroblastic anemia

Rein Jan Piso et al. Hematol Rep. .

Abstract

Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were very low (reticulocyte production index of 0.48), but bone marrow aspirate showed an accelerated erythropoiesis with ringsideroblasts. Anaemia rapidly resolved after cessation of Isoniazid. We postulate an Isoniazid induced inhibition of the δ-Amino-levulinat-synthase resulting in marked depletion of heam synthesis.

Keywords: isoniazid; sideroblastic anaemia; tuberculosis..

PubMed Disclaimer

Figures

Figure 1
Figure 1
Blood values and treatment duration. RIF, rifampin; INH, isoniazid; PZA, pyrazinamide; ETB, ethambutol; MOF, moxifloxacin; RPI, reticulocyte production index.
Figure 2
Figure 2
Hypercellular bone marrow aspirate with dysplastic erythropoiesis.
Figure 3
Figure 3
Ringsideroblasts.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Krantz SB, Zaentz SD. Pure red cell aplasia. In: Gordon A.S, Silber R, LoBue J, editors. The year in Hematology. 1977. pp. 153–90.
    1. Matthes T. Sideroblastic anemias. Ther Umsch. 2006;63:25–33. - PubMed
    1. Sharp RA, Lowe JG, Johnston RN. Antituberculous drugs and sideroblastic anaemia. Br J Clin Pract. 1990;44:706–7. - PubMed
    1. MacCurdy RK, Simon ER. Thrombocytopenia and sideroblastic anemia with pyrazinoic acid amide (pyrazinamide) therapy. Chest. 1970;57:378–81. - PubMed
    1. Vives JF, Rouy JM, Wagner A, Vallat G. Anemia with hypersideroblastosis during anti-tuberculosis therapy. cure with vitamin therapy] Nouv Rev Fr Hematol. 1978;20:99–110. - PubMed

Publication types

LinkOut - more resources