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Case Reports
. 2011 Aug 31;3(2):e18.
doi: 10.4081/hr.2011.e18. Epub 2011 Oct 20.

Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder

Alexander Pham  1 , Amir Steinberg, Brian Kwok, Angela Lopez, Stephen Lim, Michael Lill
Affiliations
Case Reports

Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder

Alexander Pham et al. Hematol Rep. .

Abstract

We present the 16th reported case of Acute Lymphoblastic Leukemia (ALL) with involvement in the bladder. Our patient was a 22 year-old man with T-cell ALL with a mediastinal mass. He received hyperfractionated cyclophos-phamide, vincristine, doxorubicin, dexamethasone (HyperCVAD) with mediastinal radiation. Prior to starting maintenance, he relapsed in the bladder and marrow. He received a nelarabine-based induction regimen and achieved remission. This was followed by an unrelated 11/12 HLA-matched myeloablative allogeneic stem cell transplant. He is in complete remission for the past 409 days.

Keywords: allogeneic stem cell transplantation.; bladder involvement; precursor t-cell acute lymphoblastic leukemia/lymphoma.

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Conflict of interest statement

Conflict of interest: the authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Hematoxylin and Eosin stain of bone marrow biopsy showing leukemic infiltration.
Figure 2
Figure 2
Terminal deoxynucleotidyl transferase stain of bone marrow biopsy.
Figure 3
Figure 3
Hematoxylin and Eosin of bladder biopsy showing leukemic infiltration.
See this image and copyright information in PMC

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