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Clinical Trial
. 2012;76(2):485-8.
doi: 10.1253/circj.cj-11-1217. Epub 2011 Dec 15.

Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension

Koichiro Sugimura  1 , Yoshihiro Fukumoto, Kimio Satoh, Kotaro Nochioka, Yutaka Miura, Tatsuo Aoki, Shunsuke Tatebe, Saori Miyamichi-Yamamoto, Hiroaki Shimokawa
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Free article
Clinical Trial

Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension

Koichiro Sugimura et al. Circ J. 2012.
Free article

Abstract

Background: Distal-type chronic thromboembolic pulmonary hypertension (CTEPH) is a fatal disease for which a new therapeutic strategy needs to be developed. We examined the effects of percutaneous transluminal pulmonary angioplasty (PTPA).

Methods and results: We prospectively enrolled 12 patients with distal-type CTEPH. After stabilizing their condition with pulmonary vasodilators, we then performed PTPA, which markedly improved pulmonary hemodynamics and pulmonary artery structure, as confirmed by angiography and optical coherence tomography, and also significantly improved their long-term prognosis compared with 39 historical controls.

Conclusions: PTPA is a promising therapeutic option for distal-type CTEPH.

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