Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2011 Oct 3;11 Spec No A(1A):S79-84.
doi: 10.1102/1470-7330.2011.9020.

NELSON lung cancer screening study

Ying Ru Zhao  1 , Xueqian Xie, Harry J de Koning, Willem P Mali, Rozemarijn Vliegenthart, Matthijs Oudkerk
Affiliations
Randomized Controlled Trial

NELSON lung cancer screening study

Ying Ru Zhao et al. Cancer Imaging. .

Abstract

The Dutch-Belgian Randomized Lung Cancer Screening Trial (Dutch acronym: NELSON study) was designed to investigate whether screening for lung cancer by low-dose multidetector computed tomography (CT) in high-risk subjects will lead to a decrease in 10-year lung cancer mortality of at least 25% compared with a control group without screening. Since the start of the NELSON study in 2003, 7557 participants underwent CT screening, with scan rounds in years 1, 2, 4 and 6. In the current review, the design of the NELSON study including participant selection and the lung nodule management protocol, as well as results on validation of CT screening and first results on lung cancer screening are described.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Baseline and 3-month follow-up CT images in a 68-year-old participant of the NELSON study. Transverse thin-section CT (a,c) and volume-rendered reconstruction (b,d) images show a lobulated pulmonary nodule with vessel attachment (boxed on a,c and green area in b,d). On the baseline scan (a,b) the volume was 303 mm3. On the 3-month follow-up CT (c,d), the volume was 576 mm3. This is consistent with a percentage volume growth of 90% and a volume-doubling time of 98 days. Histopathology of the resected nodule: squamous cell carcinoma.
See this image and copyright information in PMC

References

    1. Shibuya K, Mathers CD, Boschi-Pinto C, Lopez AD, Murray CJL. Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000. BMC Cancer. 2002;2:37. doi: 10.1186/1471-2407-2-37. - DOI - PMC - PubMed
    1. Janssen-Heijnen ML, Coebergh JW. Trends in incidence and prognosis of the histological subtypes of lung cancer in North America, Australia, New Zealand and Europe. Lung Cancer. 2001;31:123–37. doi: 10.1016/S0169-5002(00)00197-5. - DOI - PubMed
    1. Henschke CI, McCauley DI, Yankelevitz DF, et al. Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet. 1999;354:99–105. doi: 10.1016/S0140-6736(99)06093-6. - DOI - PubMed
    1. Kaneko M, Eguchi K, Ohmatsu H, et al. Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography. Radiology. 1996;201:798–802. - PubMed
    1. van Iersel CA, de Koning HJ, Draisma G, et al. Risk-based selection from the general population in a screening trial: selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON) Int J Cancer. 2006;120:868–74. doi: 10.1002/ijc.22134. - DOI - PubMed

Publication types

LinkOut - more resources