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. 2012 Mar;65(3):123-128.
doi: 10.1038/ja.2011.121. Epub 2011 Dec 21.

Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library

Toshihiko Nogawa  1 , Shunji Takahashi, Akiko Okano, Makoto Kawatani, Masakazu Uramoto, Tamio Saito, Hiroyuki Osada
Affiliations

Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library

Toshihiko Nogawa et al. J Antibiot (Tokyo). 2012 Mar.

Abstract

Two new 6,6-spiroacetal polyketides, spirotoamides A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces griseochromogenes JC82-1223 by screening of structurally unique compounds based on a search of spectral database. The fraction library was constructed using a systematic separation method to efficiently discover new metabolites from microbial sources such as actinomycetes and fungi. The structures of 1 and 2 were elucidated by 2D-NMR and mass spectrometric measurements. They belong to a class of polyketides, and contain a 6,6-spiroacetal core structure and a carboxamide group. The biosynthetic pathway of 1 and 2 is discussed in the text.

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