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Comment
. 2012 Mar;67(3):521-2.
doi: 10.1093/jac/dkr536. Epub 2011 Dec 20.

Antibiotic prophylaxis for cardiac surgery

Ruth Kappeler  1 , Margaret Gillham, Nicholas M Brown
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Comment

Antibiotic prophylaxis for cardiac surgery

Ruth Kappeler et al. J Antimicrob Chemother. 2012 Mar.

Abstract

Antibiotic prophylaxis for cardiac surgery is a controversial area. Recent systematic reviews and meta-analyses of randomized controlled trials have concluded that surgical site infection can be reduced by prolonging prophylaxis for 24-48 h. Also, post-operative pneumonia and all-cause mortality can be reduced by giving agents with both anti-Gram-negative and anti-Gram-positive activity. The choice of the most appropriate regimen remains open to debate.

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