Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 May;22(3):827-34.
doi: 10.1007/s10895-011-1017-x. Epub 2011 Dec 21.

Spectrofluorimetric assessment of hydrochlorothiazide using optical sensor nano-composite terbium ion doped in sol-gel matrix

Affiliations

Spectrofluorimetric assessment of hydrochlorothiazide using optical sensor nano-composite terbium ion doped in sol-gel matrix

A O Youssef. J Fluoresc. 2012 May.

Abstract

A new, simple, sensitive and selective spectrofluorimetric method for the determination of Hydrochlorothiazide was developed in acetonitrile at pH 6.2. The Hydrochlorothiazide can remarkably enhance the luminescence intensity of the Tb(3+) ion doped in sol-gel matrix at λ(ex) = 370 nm. The intensity of the emission band of Tb(3+) ion doped in sol-gel matrix was increased due to the energy transfer from the triplet excited state of Hydrochlorothiazide to ((5)D(4)) excited energy state of Tb(3) ion. The enhancement of the emission band of Tb(3+) ion doped in sol-gel matrix at ((5)D(4)→(7)F(5)) 545 nm was directly proportion to the concentration of Hydrochlorothiazide with a dynamic ranges of 5.0 × 10(-10)-5.0 × 10(-6) mol L(-1) and detection limit of 2.2 × 10(-11) mol L(-1).

PubMed Disclaimer

References

    1. Analyst. 1978 Apr;103(1225):354-8 - PubMed
    1. J Pharm Biomed Anal. 2004 Feb 4;34(2):433-40 - PubMed
    1. J Fluoresc. 2011 Jul;21(4):1739-48 - PubMed
    1. Talanta. 2011 Mar 15;84(1):27-33 - PubMed
    1. Pharm Res. 1990 Dec;7(12):1257-61 - PubMed

LinkOut - more resources