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Review
. 2012 Jan;61(1):23-9.
doi: 10.2337/db11-0555.

Nutrient sensing, autophagy, and diabetic nephropathy

Shinji Kume  1 , Merlin C Thomas, Daisuke Koya
Affiliations
Review

Nutrient sensing, autophagy, and diabetic nephropathy

Shinji Kume et al. Diabetes. 2012 Jan.
No abstract available

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Figures

FIG. 1.
FIG. 1.
The potential role of nutrient-sensing pathways in the pathogenesis of diabetes complications.
FIG. 2.
FIG. 2.
The three nutrient-sensing pathways, mTOR, AMPK, and SIRT1, may be independently and coordinately involved in the pathogenesis of diabetic nephropathy. 4E-BP, 4E-binding protein; COX2, cyclooxygenase-2; eNOS, endothelial nitric oxide synthase; EPO, erythropoietin; FoxO, forkhead box class O; Hif2α, hypoxia-inducible factor 2α; IGF1, insulin-like growth factor 1; NO, nitric oxide; PKB, protein kinase B; ROS, reactive oxygen species; TSC, tuberous sclerosis complex.
See this image and copyright information in PMC

References

    1. Imai S, Guarente L. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci 2010;31:212–220 - PMC - PubMed
    1. Steinberg GR, Kemp BE. AMPK in Health and Disease. Physiol Rev 2009;89:1025–1078 - PubMed
    1. Wellen KE, Thompson CB. Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell 2010;40:323–332 - PMC - PubMed
    1. Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011;12:21–35 - PMC - PubMed
    1. Hallows KR, Mount PF, Pastor-Soler NM, Power DA. Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol 2010;298:F1067–F1077 - PMC - PubMed

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