Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jan;1(1):366-71.
doi: 10.1159/000330467. Epub 2011 Nov 5.

Ceruloplasmin and iron proteins in the serum of patients with Alzheimer's disease

Gudlaug Torsdottir  1 , Jakob Kristinsson, Jón Snaedal, Torkell Jóhannesson
Affiliations

Ceruloplasmin and iron proteins in the serum of patients with Alzheimer's disease

Gudlaug Torsdottir et al. Dement Geriatr Cogn Dis Extra. 2011 Jan.

Abstract

Backgrounds/aims: The oxidative activity of ceruloplasmin (CP) in serum has been found to be lowered in patients with Alzheimer's disease (AD). We investigated whether changes in CP were reflected by altered iron parameters in AD patients.

Methods: Iron parameters, and CP concentration, activity and specific activity were determined in the serum of 41 AD patients and controls.

Results: CP activity and specific activity were significantly lower in the AD patients. CP concentration and activity were negatively correlated with the ferritin concentration in both groups. CP concentration was positively correlated with age in the control group but not in the patients group.

Conclusion: The lowered CP activity in the serum of AD patients was not reflected by the iron parameters. As CP concentration only rises with age in the controls, this may indicate failing adaption to age-related alterations in iron metabolism in AD patients.

Keywords: Alzheimer's disease; Ceruloplasmin; Ferritin; Iron; Oxidative activity; Transferrin.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR. Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci. 2004;5:863–873. - PubMed
    1. Quintana C, Bellefqih S, Laval JY, Guerquin-Kern JL, Wu TD, Avila J, et al. Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level. J Struct Biol. 2006;153:42–54. - PubMed
    1. Hochstrasser H, Bauer P, Walter U, Behnke S, Spiegel J, Csoti I, et al. Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease. Neurology. 2004;63:1912–1917. - PubMed
    1. Yoshida K, Kaneko K, Miyajima H, Tokuda T, Nakamura A, Kato M, et al. Increased lipid peroxidation in the brains of aceruloplasminemia patients. J Neurol Sci. 2000;175:91–95. - PubMed
    1. Xu X, Pin S, Gathinji M, Fuchs R, Harris ZL. Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis. Ann NY Acad Sci. 2004;1012:299–305. - PubMed