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. 2011 Jan;1(1):366-71.
doi: 10.1159/000330467. Epub 2011 Nov 5.

Ceruloplasmin and iron proteins in the serum of patients with Alzheimer's disease

Gudlaug Torsdottir  1 , Jakob Kristinsson, Jón Snaedal, Torkell Jóhannesson
Affiliations

Ceruloplasmin and iron proteins in the serum of patients with Alzheimer's disease

Gudlaug Torsdottir et al. Dement Geriatr Cogn Dis Extra. 2011 Jan.

Abstract

Backgrounds/aims: The oxidative activity of ceruloplasmin (CP) in serum has been found to be lowered in patients with Alzheimer's disease (AD). We investigated whether changes in CP were reflected by altered iron parameters in AD patients.

Methods: Iron parameters, and CP concentration, activity and specific activity were determined in the serum of 41 AD patients and controls.

Results: CP activity and specific activity were significantly lower in the AD patients. CP concentration and activity were negatively correlated with the ferritin concentration in both groups. CP concentration was positively correlated with age in the control group but not in the patients group.

Conclusion: The lowered CP activity in the serum of AD patients was not reflected by the iron parameters. As CP concentration only rises with age in the controls, this may indicate failing adaption to age-related alterations in iron metabolism in AD patients.

Keywords: Alzheimer's disease; Ceruloplasmin; Ferritin; Iron; Oxidative activity; Transferrin.

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