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. 2011:2011:587303.
doi: 10.4061/2011/587303. Epub 2011 Dec 10.

Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project

Daniel Bia  1 , Yanina Zócalo, Ignacio Farro, Juan Torrado, Federico Farro, Lucía Florio, Alicia Olascoaga, Javier Brum, Walter Alallón, Carlos Negreira, Ricardo Lluberas, Ricardo L Armentano
Affiliations

Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project

Daniel Bia et al. Int J Hypertens. 2011.

Abstract

This work was carried out in a Uruguayan (South American) population to characterize aging-associated physiological arterial changes. Parameters markers of subclinical atherosclerosis and that associate age-related changes were evaluated in healthy people. A conservative approach was used and people with nonphysiological and pathological conditions were excluded. Then, we excluded subjects with (a) cardiovascular (CV) symptoms, (b) CV disease, (c) diabetes mellitus or renal failure, and (d) traditional CV risk factors (other than age and gender). Subjects (n = 388) were submitted to non-invasive vascular studies (gold-standard techniques), to evaluate (1) common (CCA), internal, and external carotid plaque prevalence, (2) CCA intima-media thickness and diameter, (3) CCA stiffness (percentual pulsatility, compliance, distensibility, and stiffness index), (4) aortic stiffness (carotid-femoral pulse wave velocity), and (5) peripheral and central pressure wave-derived parameters. Age groups: ≤20, 21-30, 31-40, 41-50, 51-60, 61-70, and 71-80 years old. Age-related structural and functional vascular parameters profiles were obtained and analyzed considering data from other populations. The work has the strength of being the first, in Latin America, that uses an integrative approach to characterize vascular aging-related changes. Data could be used to define vascular aging and abnormal or disease-related changes.

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Figures

Figure 1
Figure 1
(a) Software employed to the CIMT and instantaneous diameter waveform measurement from B-Mode echographic videos. (b) Software employed to the PWV measurement from the carotid (Canal 1) and femoral (Canal 1) instantaneous waveforms. (c) Software employed to obtain the central pressure waveform (from the radial waveform recording) and to perform the peripheral and central pressure waveform analysis. (d) Schema of the pulse wave analysis (see text).
Figure 2
Figure 2
Peripheral (radial) and central (aortic) systolic and diastolic blood pressure (a), pulse pressure amplification ratio (b), and heart rate (c) age- (decade-) related profiles.
Figure 3
Figure 3
Peripheral (a) and central (b and c) wave reflections indexes age- (decade-) related profiles.
Figure 4
Figure 4
Carotid atherosclerotic plaque prevalence (a) and common carotid artery (CCA) intima-media thickness (b), diameters (c), and wall-to-lumen ratio (d) age- (decade-) related profiles.
Figure 5
Figure 5
Common carotid artery (CCA) local stiffness parameters. CCA percentual or fractional pulsatility (a), compliance (b), distensibility (c), and Beta or stiffness index (d) age- (decade-) related profiles.
Figure 6
Figure 6
Measured and “real” carotid-femoral pulse wave velocity (PWVcf) age- (decade-) related profiles.
See this image and copyright information in PMC

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