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Review
. 2012 Mar;14(3):343-55.
doi: 10.1111/j.1462-5822.2011.01741.x. Epub 2012 Feb 2.

The role of the spleen in malaria

Hernando A Del Portillo  1 , Mireia Ferrer, Thibaut Brugat, Lorena Martin-Jaular, Jean Langhorne, Marcus V G Lacerda
Affiliations
Review

The role of the spleen in malaria

Hernando A Del Portillo et al. Cell Microbiol. 2012 Mar.

Abstract

The spleen is a complex organ that is perfectly adapted to selectively filtering and destroying senescent red blood cells (RBCs), infectious microorganisms and Plasmodium-parasitized RBCs. Infection by malaria is the most common cause of spleen rupture and splenomegaly, albeit variably, a landmark of malaria infection. Here, the role of the spleen in malaria is reviewed with special emphasis in lessons learned from human infections and mouse models.

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