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. 2011 Dec 21:6:126.
doi: 10.1186/1746-1596-6-126.

Diagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China

Qingbin Song  1 , Deguang Wang, Yi Lou, Changsi Li, Changqing Fang, Xiangmin He, Jianhua Li
Affiliations

Diagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China

Qingbin Song et al. Diagn Pathol. .

Abstract

Background: To evaluate the expression and differential diagnostic significance of CK19, TG, Ki67 and galectin-3 in papillary thyroid carcinoma (PTC) (metastatic and non metastatic), follicular adenoma and nodular goiter in patients from the northeastern part of China.

Methods: 441 PTC specimens and 151 other benign thyroid specimens (97 cases of nodular goiter, 54 cases of nonmalignant follicular adenoma) were collected. Immunohistochemistry for CK19, TG, Ki67 and galectin-3 was performed.

Results: CK19, TG, Ki67 and galectin-3 expression was 96.37% (425/441), 82.77% (365/441), and 40.59% (179/441), 96.82% (427/441), respectively, for the PTC group and the expression of these markers in the benign thyroid lesions group was 25.83% (39/151), 79.47% (120/151), and 37.09% (56/151), 50.99% (77/151), respectively. The expression of CK19 and galectin-3 in PTC was much higher than that in the nonmalignant group (p < 0.05). However, the expression of TG, Ki67 did not differ among these two groups (p > 0.05). The diagnostic efficiency of CK19 and galectin-3 for PTC was 96.37% (537/592) and 84.63% (501/592). CK19 and galectin-3 expression rate in PTC was higher than that in benign disease cases.

Conclusions: The diagnostic efficiency of CK19 for PTC was slightly better than galectin-3. The utilization of these markers combined with morphologic evaluation may be helpful in the differential diagnosis of papillary thyroid carcinoma in the northeastern region of China.

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Figures

Figure 1
Figure 1
CK19, TG, Ki67 and galectin-3 immunoreactivity in PTC and nonmalignant thyroid lesion. A-E: HE, CK19, TG, Ki67 and galectin-3 staining in PTC; a-e: HE, CK19, TG, Ki67 and galectin-3 staining in nonmalignant thyroid lesion. Scale bar: 50 μm.
Figure 2
Figure 2
CK19, TG, Ki67 and galectin-3 positive rate in nodular goiter, follicular adenoma, papillary thyroid carcinoma without lymphatic metastasis and papillary thyroid carcinoma with lymphatic metastasis. PTC 1: papillary thyroid carcinoma (PTC) without lymphatic metastasis; PTC 2: papillary thyroid carcinoma (PTC) with lymphatic metastasis.
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References

    1. Nikiforov YE. In: Diagnostic Pathology and Molecular Genetics of the Thyroid. Nikiforov YE, Biddinger PW, Thompson LDR, editor. Lippincott Williams & Wilkins, Baltimore, MA; 2009. Thyroid tumors: classification and general considerations; pp. 94–102.
    1. DeVita VT, Hellman JS, Rosenberg SA. Cancer: principles and practice of oncology. Lippincott Williams & Wilkins. 2008. pp. 1674–1699. - PubMed
    1. Sethi K, Sarkar S, Das S, Mohanty B, Mandal M. Biomarkers for the diagnosis of thyroid cancer. J Exp Ther Oncol. 2010;8:341–352. - PubMed
    1. Kato MA, Fahey TJ. Molecular markers in thyroid cancer diagnostics. Surg Clin North Am. 2009;89:1139–1155. doi: 10.1016/j.suc.2009.06.012. - DOI - PubMed
    1. Nikiforov YE. Molecular analysis of thyroid tumors. Mod Pathol Suppl. 2011;2:34–43. - PubMed

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