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Randomized Controlled Trial
. 2012 Mar;31(3):306-8.
doi: 10.1097/INF.0b013e3182458289.

Small randomized trial among low-birth-weight children receiving bacillus Calmette-Guérin vaccination at first health center contact

Sofie Biering-Sørensen  1 , Peter Aaby, Bitiguida Mutna Napirna, Adam Roth, Henrik Ravn, Amabelia Rodrigues, Hilton Whittle, Christine Stabell Benn
Affiliations
Randomized Controlled Trial

Small randomized trial among low-birth-weight children receiving bacillus Calmette-Guérin vaccination at first health center contact

Sofie Biering-Sørensen et al. Pediatr Infect Dis J. 2012 Mar.

Abstract

A total of 105 low-birth-weight children presenting for first vaccination were randomized to receive bacillus Calmette-Guérin (BCG) immediately or later (current practice). The mortality rate ratio for BCG was 0.17 (95% CI = 0.02-1.35) within 3 days of enrollment, 0.28 (0.06-1.37) in the first month, and 0.27 (0.07-0.98) after 2 months of age. The mortality rate ratio was 0.41 (0.14-1.18) (P = 0.098) in infancy. Administration of BCG vaccine at first contact may contribute to lower mortality.

Trial registration: ClinicalTrials.gov NCT00146302.

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