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. 2011:2011:872057.
doi: 10.1155/2011/872057. Epub 2011 Dec 5.

Nonsurgical transurethral radiofrequency collagen denaturation: results at three years after treatment

Denise M Elser  1 , Gretchen K Mitchell, John R Miklos, Kevin G Nickell, Kevin Cline, Harvey Winkler, W Glen Wells
Affiliations

Nonsurgical transurethral radiofrequency collagen denaturation: results at three years after treatment

Denise M Elser et al. Adv Urol. 2011.

Abstract

Objective. To assess treatment efficacy and quality of life in women with stress urinary incontinence 3 years after treatment with nonsurgical transurethral radiofrequency collagen denaturation. Methods. This prospective study included 139 women with stress urinary incontinence due to bladder outlet hypermobility. Radiofrequency collagen denaturation was performed using local anesthesia in an office setting. Assessments included incontinence quality of life (I-QOL) and urogenital distress inventory (UDI-6) instruments. Results. In total, 139 women were enrolled and 136 women were treated (mean age, 47 years). At 36 months, intent-to-treat analysis (n = 139) revealed significant improvements in quality of life. Mean I-QOL score improved 17 points from baseline (P = .0004), while mean UDI-6 score improved (decreased) 19 points (P = .0005). Conclusions. Transurethral collagen denaturation is a low-risk, office-based procedure that results in durable quality-of-life improvements in a significant proportion of women for as long as 3 years.

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Figures

Figure 1
Figure 1
Patient disposition. *Two validated questionnaires, the incontinence quality of life and the urogenital distress inventory instruments, were completed at 36 months.
See this image and copyright information in PMC

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