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Comparative Study
. 2011 Dec 22:11:37.
doi: 10.1186/1471-2482-11-37.

Bovine pericardium retail preserved in glutaraldehyde and used as a vascular patch

Wladimir F Saporito  1 , Adílson C Pires, Sérgio H Cardoso, João A Correa, Luiz Carlos de Abreu, Vitor E Valenti, Luciano M R Miller, Eduardo Colombari
Affiliations
Comparative Study

Bovine pericardium retail preserved in glutaraldehyde and used as a vascular patch

Wladimir F Saporito et al. BMC Surg. .

Abstract

Background: In this study we evaluated the performance of bovine pericardium preserved in glutaraldehyde used as a vascular patch.

Methods: Fourteen young pigs, six females and eight males, weighting 10.3 - 18.4 kg were used in our study. We implanted three remnants in each pig, two in the abdominal aorta and one was juxtaposed to the peritoneum. The smooth face (SF) and rough face (RF) of each remnant were implanted turned to the vessel inner portion and one remnant was juxtaposed to the peritoneum. The animals were sacrificed in 4.5 - 8 months after surgery (75 - 109 kg). The remnants were assessed for aorta wall, fibroses formation in inner apposition and calcification related to the face turned to the vessel inner portion.

Results: The rough face showed a lower dilatation level compared to the face implanted in adjacent aorta. There was no difference between intensity and/or incidence of graft calcification when the superficies were compared. The bovine pericardium preserved in glutaraldehyde did not show alterations in its structure when implanted with different faces turned to the inner portion of vessel.

Conclusion: When turned to the inner portion of the vessel, the rough face of the remnant presented a lower dilatation in relation to the adjacent aorta and a better quality of endothelium layer and did not show a difference between intensity and/or incidence of graft calcification.

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Figures

Figure 1
Figure 1
(A) Overview of the surgical field. (B) Retail is implanted in the abdominal aorta. Immediate aspect. (C) Bovine pericardium patch implanted in the aorta and peritoneum. (D) Overview of bovine pericardium implanted in the aorta. Final aspect. Arrows indicate the position of the implants.
Figure 2
Figure 2
(A) Aspect of the patch at the postoperative period (animal 3). (B) Aspect of the patch at the postoperative period (animal 7). (C) Aspect of the patch at the postoperative period (animal 11). (D) Retail integrated to the aorta. Arrows indicate the position of the implants.
Figure 3
Figure 3
(A) Aspect of the structure of the patch with calcification (hematoxylin - eosin - 4×). (B) Aspect of the cover layer on the inner face of the patch (RF) (hematoxylin- eosin- 4×). (C) Aspect of the cover layer on the inner face of the patch (SF) (hematoxylin - eosin - 4×). (D) Aspect of the cover layer on the inner face of the patch (RF) (Verhoeff - 4×). Arrows indicate calcification.
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