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Review
. 2011 Dec 22;14(1):38-45.
doi: 10.1038/ncb2381.

Shaping development with ESCRTs

Tor Erik Rusten  1 , Thomas Vaccari, Harald Stenmark
Affiliations
Review

Shaping development with ESCRTs

Tor Erik Rusten et al. Nat Cell Biol. .

Abstract

Originally identified for their involvement in endosomal sorting and multivesicular endosome (MVE) biogenesis, components of the endosomal sorting complex required for transport (ESCRT) are now known to control additional cellular functions such as receptor signalling, cytokinesis, autophagy, polarity, migration, miRNA activity and mRNA transport. The diverse cell biological functions of ESCRT proteins are translated into a pleiotropic set of developmental trajectories that reflect the wide repertoire of these evolutionarily conserved proteins.

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