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Review
. 2012 Feb;7(2):358-65.
doi: 10.2215/CJN.04040411. Epub 2011 Dec 22.

Vitamin D therapy in chronic kidney disease and end stage renal disease

Michal L Melamed  1 , Ravi I Thadhani
Affiliations
Review

Vitamin D therapy in chronic kidney disease and end stage renal disease

Michal L Melamed et al. Clin J Am Soc Nephrol. 2012 Feb.

Abstract

Vitamin D has garnered much research and debate about supplementation in recent years, not only as it pertains to patients with kidney disease but also to those in the general population. This review discusses observational and available clinical trial evidence about the effects of both calcitriol and vitamin D analogs (active) and ergocalciferol and cholecalciferol (nutritional) vitamin D in patients with CKD and ESRD.

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Figures

Figure 1.
Figure 1.
Physiology of vitamin D in the body. It circulates as 25-hydroxyvitamin D (25D), which then gets converted in the kidney to 1,25-dihydroxyvitamin D (1,25D). The 1,25D has endocrine effects, shown at the right. 25D can also be taken up by monocytes and other cells where it is converted to 1,25D acting in an autocrine fashion to upregulate cathelicidin production.
See this image and copyright information in PMC

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