Review
doi: 10.1093/abbs/gmr108.
Large chromatin domains in pluripotent and differentiated cells
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- PMID: 22194013
- DOI: 10.1093/abbs/gmr108
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Review
Large chromatin domains in pluripotent and differentiated cells
Acta Biochim Biophys Sin (Shanghai).
2012 Jan.
Free article
Abstract
Pluripotent stem cells are able to proliferate unlimitedly and to generate all somatic cell types, thus holding a great promise in medical applications. Epigenetic modifications are believed to play crucial roles in regulating pluripotency and differentiation. Recent genome-wide studies on mammalian systems have revealed several types of large chromatin domains which are associated with higher-order organization of the genome. The elucidation of genomic distribution and dynamics of these domains have shed light on the mechanisms underling pluripotency and lineage commitment.
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