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Comment
. 2011 Dec 22;118(26):6987-8.
doi: 10.1182/blood-2011-10-385278.

Nuclear JAK2

Mark A Dawson, Andrew J Bannister, Lindsay Saunders, Omar-Abdel Wahab, Fan Liu, Stephen D Nimer, Ross L Levine, Berthold Göttgens, Tony Kouzarides, Anthony R Green
Comment

Nuclear JAK2

Mark A Dawson et al. Blood. .
No abstract available

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Figures

Figure 1
Figure 1
JAK2 is present in both the cytoplasm and the nucleoplasm. (A) Subcellular fractionation was performed in Ba/F3 EPO-R and TF-1 cell lines stably expressing a JAK2V617F EGFP fusion construct and subcellular distribution was assessed by immunoblotting. Endogenous JAK2 and JAK2 GFP Fusion protein were present in both the cytoplasm [C] and the nucleoplasm [N]. α-tubulin was used as a cytoplasmic marker. (B) JAK2 compartmentalizes to both the nuclear and cytoplasmic fractions in fractionation experiments in a panel of leukemic cell lines expressing endogenous JAK2V617F mutation (SET2, UKE1, and HEL).
See this image and copyright information in PMC

Comment on

References

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