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Review
. 2011 Dec;7(12):e1002324.
doi: 10.1371/journal.ppat.1002324. Epub 2011 Dec 15.

Comparative pathobiology of fungal pathogens of plants and animals

Affiliations
Review

Comparative pathobiology of fungal pathogens of plants and animals

Martin B Dickman et al. PLoS Pathog. 2011 Dec.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Tipping the balance for control in host–pathogen interactions; generalized schematic.
To become established in plants or animals, fungal pathogens attempt to disrupt host cell homeostasis while avoiding and/or suppressing host recognition. The host has sophisticated surveillance systems that are poised to rapidly recognize non-self and counter disruptive attempts by pathogens. Signals activated by these surveillance systems can initiate a myriad of host defenses, including the release of reactive oxygen species and hydrolytic enzymes, which thwart the activities of fungal pathogens. The activation of host defense mechanisms also often culminates in the programmed death of host cells or tissue, which limits pathogen spread or dissemination. If attempts by the pathogen to co-opt, subvert, or avoid these host recognition and signaling mechanisms succeed, then the pathogen “wins” the battle for control of the interaction, and disease ensues. If the host wins this battle, then disease is averted.

References

    1. Kensler TW, Roebuck BD, Wogan GN, Groopman JD. Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicol Sci. 2011;120(Suppl 1):S28–S48. - PMC - PubMed
    1. Kim KS, Min JY, Dickman MB. Oxalic acid is an elicitor of plant programmed cell death during Sclerotinia sclerotiorum disease development. Mol Plant Microbe Interact. 2008;21:605–612. - PubMed
    1. Stockmann-Juvala H, Savolainen K. A review of the toxic effects and mechanisms of action of fumonisin B1. Hum Exp Toxicol. 2008;27:799–809. - PubMed
    1. Gopee NV, He Q, Sharma RP. Fumonisin B1-induced apoptosis is associated with delayed inhibition of protein kinase C, nuclear factor-kappaB and tumor necrosis factor alpha in LLC-PK1 cells. Chem Biol Interact. 2003;146:131–145. - PubMed
    1. Huang C, Dickman M, Henderson G, Jones C. Repression of protein kinase C and stimulation of cyclic AMP response elements by fumonisin, a fungal encoded toxin which is a carcinogen. Cancer Res. 1995;55:1655–1659. - PubMed

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