Beneficial effect of ultra-low-dose aspirin in platelet activity alterations and haemorrhage observed in experimental portal hypertension
- PMID: 22195282
- PMCID: PMC3236533
- DOI: 10.1155/2012/430460
Beneficial effect of ultra-low-dose aspirin in platelet activity alterations and haemorrhage observed in experimental portal hypertension
Abstract
Ultra-low-dose aspirin has shown a prothrombotic effect in the laser-induced thrombosis model. Several studies of our laboratory have shown a positive effect in rats with two different experimental models of portal hypertension: portal vein ligation, a model with an almost normal liver, and 30 days of bile duct ligation, a model with cirrhosis and presence of ascitis. In both models of portal hypertensive rats, bleeding time was prolonged and thrombi formation, in a laser-induced model of thrombi production, decreased. The hypotheses of the presented studies were that ultra-low-dose aspirin could decrease the bleeding complications in these models and that the mechanism for these effects could act thorough the COX pathway. In different studies, ultra-low dose of aspirin normalized the induced hemorrhage time, thrombi production, and platelet-endothelial cell interaction. The possible beneficial role of these doses of aspirin and mechanism of COX 2 inhibition are discussed.
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References
-
- Garcia-Tsao G, Bosch J. Management of varices and variceal hemorrhage in cirrhosis. New England Journal of Medicine. 2010;362(9):823–832. - PubMed
-
- Lisman T, Leebeek FW, de Groot PG. Haemostatic abnormalities in patients with liver disease. Journal of Hepatology. 2002;37(2):280–287. - PubMed
-
- Thomas DP, Ream VJ, Stuart RK. Platelet aggregation in patients with Laennec’s cirrhosis of the liver. New England Journal of Medicine. 1967;276(24):1344–1348. - PubMed
-
- Thomas DP. Abnormalities of platelet aggregation in patients with alcoholic cirrhosis. Annals of the New York Academy of Sciences. 1972;201:243–250. - PubMed
-
- Ordinas A, Maragall S, Castillo R, Nurden AT. A glycoprotein I defect in the platelets of three patients with severe cirrhosis of the liver. Thrombosis Research. 1978;13(2):297–302. - PubMed
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