Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990;18(4):295-8.
doi: 10.1007/BF00294778.

Transforming growth factor beta-like activity in human hydrocele fluid

P K Saha  1 , S Kanda, H Morimitsu, N Nishimura, H Kanetake, Y Saito
Affiliations

Transforming growth factor beta-like activity in human hydrocele fluid

P K Saha et al. Urol Res. 1990.

Abstract

In this study transforming growth factor beta (TGF-beta)-like activity in human hydrocele fluid was investigated. Inhibition of DNA synthesis of adult rat hepatocytes in primary culture and stimulation of colony formation of normal rat kidney (NRK) fibroblasts, clone 49F in soft agar were observed in all acidified hydrocele fluids and these activities were neutralized by the specific antibody raised against human native TGF-beta. In samples obtained from recurrent cases of hydrocele, TGF beta-like activity was observed in its active form (without acidification). These results suggest that human hydrocele fluid contains TGF beta-like activity and that the active form of TGF-beta in recurrent hydrocele fluid may be responsible for the recurrence of the disease even after repeated aspiration.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Cancer Res. 1988 Apr 1;48(7):1792-7 - PubMed
    1. Jpn J Cancer Res. 1987 Aug;78(8):814-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Aug;75(8):4001-5 - PubMed
    1. Cancer Res. 1986 May;46(5):2330-4 - PubMed
    1. J Biol Chem. 1972 Dec 10;247(23):7609-11 - PubMed

Substances