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Comment
. 2011 Dec 22;72(6):885-7.
doi: 10.1016/j.neuron.2011.12.008.

De novo CNVs in bipolar disorder: recurrent themes or new directions?

Santhosh Girirajan  1 , Evan E Eichler
Affiliations
Free article
Comment

De novo CNVs in bipolar disorder: recurrent themes or new directions?

Santhosh Girirajan et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Malhotra and colleagues report an enrichment of de novo copy number variants in bipolar disorder and schizophrenia when compared with those of controls. The study highlights the importance of a genetic model involving rare and disruptive variants to further our understanding of complex neuropsychiatric traits.

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  • High frequencies of de novo CNVs in bipolar disorder and schizophrenia.
    Malhotra D, McCarthy S, Michaelson JJ, Vacic V, Burdick KE, Yoon S, Cichon S, Corvin A, Gary S, Gershon ES, Gill M, Karayiorgou M, Kelsoe JR, Krastoshevsky O, Krause V, Leibenluft E, Levy DL, Makarov V, Bhandari A, Malhotra AK, McMahon FJ, Nöthen MM, Potash JB, Rietschel M, Schulze TG, Sebat J. Malhotra D, et al. Neuron. 2011 Dec 22;72(6):951-63. doi: 10.1016/j.neuron.2011.11.007. Neuron. 2011. PMID: 22196331 Free PMC article.