Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan 11;12(1):512-7.
doi: 10.1021/nl204098n. Epub 2011 Dec 29.

DNA origami nanopores

Nicholas A W Bell  1 , Christian R Engst, Marc Ablay, Giorgio Divitini, Caterina Ducati, Tim Liedl, Ulrich F Keyser
Affiliations

DNA origami nanopores

Nicholas A W Bell et al. Nano Lett. .

Abstract

We demonstrate the assembly of functional hybrid nanopores for single molecule sensing by inserting DNA origami structures into solid-state nanopores. In our experiments, single artificial nanopores based on DNA origami are repeatedly inserted in and ejected from solid-state nanopores with diameters around 15 nm. We show that these hybrid nanopores can be employed for the detection of λ-DNA molecules. Our approach paves the way for future development of adaptable single-molecule nanopore sensors based on the combination of solid-state nanopores and DNA self-assembly.

PubMed Disclaimer

Publication types