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Review
. 2011 Oct;4(4):295-305.
doi: 10.2174/1874471011104040295.

Targeted alpha therapy with 213Bi

Alfred Morgenstern  1 , Frank Bruchertseifer, Christos Apostolidis
Affiliations
Review

Targeted alpha therapy with 213Bi

Alfred Morgenstern et al. Curr Radiopharm. 2011 Oct.

Abstract

The potential of targeted therapy with the alpha emitter 213Bi has been successfully demonstrated in a large number of preclinical studies and several clinical trials have provided evidence for its feasibility, safety and therapeutic efficacy. This review describes methods for the production of 225Ac and 225Ac/213Bi radionuclide generators, gives an overview of selected preclinical studies and summarizes the current clinical experience with 213Bi.

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