Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2012 Jun;19(6):697-703.
doi: 10.1097/gme.0b013e31823bcec5.

Treatment with hormone therapy and calcitriol did not affect depression in older postmenopausal women: no interaction with estrogen and vitamin D receptor genotype polymorphisms

Vinod Yalamanchili  1 , J Christopher Gallagher
Affiliations
Randomized Controlled Trial

Treatment with hormone therapy and calcitriol did not affect depression in older postmenopausal women: no interaction with estrogen and vitamin D receptor genotype polymorphisms

Vinod Yalamanchili et al. Menopause. 2012 Jun.

Abstract

Objective: The aim of this study was to examine the effect of hormone therapy and calcitriol on depression in older postmenopausal women and to determine whether the response was associated with polymorphisms of estrogen receptor α and vitamin D receptor.

Methods: In a double-blind placebo-controlled prospective trial involving 489 postmenopausal older women, a secondary analysis of depression was done. The Geriatric Depression Scale was used to screen for depression. We used binary logistic regression to examine the effect of treatment on depression and one-way analysis of variance to find a relationship between gene polymorphisms and depression.

Results: There was no effect of hormone therapy (odds ratio [OR], 1.65; 95% CI, 0.66-4.12; P = 0.277), calcitriol (OR, 1.15; 95% CI, 0.43-3.11; P = 0.772), or hormone therapy with calcitriol (OR, 1.01; 95% CI, 0.36-2.80; P = 0.979) on depression. Neither the polymorphisms of estrogen receptor α (XbaI-β = 0.093; CI, -0.337 to 1.350; P = 0.239 and PvuII-β = -0.064; CI, -1.171 to 0.491, P = 0.421) nor those of vitamin D receptor (BsmI-β = 0.044, CI -2.546 to 3.030, P = 0.865 and TaqI-β = -0.015, CI -2.900 to 2.738, P = 0.955) were associated with depression.

Conclusion: In older postmenopausal women, there was no effect of hormone therapy and calcitriol either individually or in combination with depression. Estrogen receptor α and vitamin D receptor polymorphisms are not associated with depression or the response to intervention in older postmenopausal women. Additional trials are required to confirm these findings.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Comparison of mean change in GDS scores in depressed and non-depressed people. Error bars represent 95% C.I. HT-Hormone Therapy with conjugated equine estrogens 0.625 mg/daily in hysterectomized women or combined with medroxyprogesterone acetate 2.5 mg/daily in women with intact uterus. Calcitriol - 0.25g twice daily. Y-axis represents mean of difference between final GDS and baseline GDS.
See this image and copyright information in PMC

References

    1. Gottfries CG. Late life depression. Eur Arch Psychiatry Clin Neurosci. 2001;251(Suppl 2):II57–61. - PubMed
    1. Ina K, Hayashi T, Nomura H, Ishitsuka A, Hirai H, Iguchi A. Depression, quality of life (QoL) and will to live of community-dwelling postmenopausal women in three Asian countries: Korea, China and Japan. Arch Gerontol Geriatr. 2011 Jul-Aug;53(1):8–12. - PubMed
    1. Borowiak E, Kostka T. Predictors of quality of life in older people living at home and in institutions. Aging Clin Exp Res. 2004;16(3):212–220. - PubMed
    1. Klap R, Unroe KT, Unutzer J. Caring for mental illness in the United States: a focus on older adults. Am J Geriatr Psychiatry. 2003;11(5):517–524. - PubMed
    1. Gallo JJ, Rabins PV. Depression without sadness: alternative presentations of depression in late life. Am Fam Physician. 1999;60(3):820–826. - PubMed

Publication types

MeSH terms