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Review
. 2012 Mar;132(3 Pt 2):797-810.
doi: 10.1038/jid.2011.434. Epub 2011 Dec 29.

25 years of epidermal stem cell research

Ruby Ghadially  1
Affiliations
Review

25 years of epidermal stem cell research

Ruby Ghadially. J Invest Dermatol. 2012 Mar.

Abstract

This is a chronicle of concepts in the field of epidermal stem cell biology and a historic look at their development over time. The past 25 years have seen the evolution of epidermal stem cell science, from first fundamental studies to a sophisticated science. The study of epithelial stem cell biology was aided by the ability to visualize the distribution of stem cells and their progeny through lineage analysis studies. The excellent progress we have made in understanding epidermal stem cell biology is discussed in this article. The challenges we still face in understanding epidermal stem cells include defining molecular markers for stem and progenitor sub-populations, determining the locations and contributions of the different stem cell niches, and mapping regulatory pathways of epidermal stem cell proliferation and differentiation. However, our rapidly evolving understanding of epidermal stem cells has many potential uses that promise to translate into improved patient therapy.

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Figures

FIGURE 1
FIGURE 1
There was an exponential increase in epidermal stem cell publications from 1985 to 2010.
FIGURE 2
FIGURE 2
FIGURE 3
FIGURE 3
The field of epidermal stem cell research was born 20 years after that of hematopoietic stem cell research.
See this image and copyright information in PMC

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