Transfer of metabolites across the peroxisomal membrane
- PMID: 22206997
- DOI: 10.1016/j.bbadis.2011.12.011
Transfer of metabolites across the peroxisomal membrane
Abstract
Peroxisomes perform a large variety of metabolic functions that require a constant flow of metabolites across the membranes of these organelles. Over the last few years it has become clear that the transport machinery of the peroxisomal membrane is a unique biological entity since it includes nonselective channels conducting small solutes side by side with transporters for 'bulky' solutes such as ATP. Electrophysiological experiments revealed several channel-forming activities in preparations of plant, mammalian, and yeast peroxisomes and in glycosomes of Trypanosoma brucei. The properties of the first discovered peroxisomal membrane channel - mammalian Pxmp2 protein - have also been characterized. The channels are apparently involved in the formation of peroxisomal shuttle systems and in the transmembrane transfer of various water-soluble metabolites including products of peroxisomal β-oxidation. These products are processed by a large set of peroxisomal enzymes including carnitine acyltransferases, enzymes involved in the synthesis of ketone bodies, thioesterases, and others. This review discusses recent data pertaining to solute permeability and metabolite transport systems in peroxisomal membranes and also addresses mechanisms responsible for the transfer of ATP and cofactors such as an ATP transporter and nudix hydrolases.
Copyright © 2012 Elsevier B.V. All rights reserved.
Similar articles
-
Peroxisomal membrane permeability and solute transfer.Biochim Biophys Acta. 2006 Dec;1763(12):1697-706. doi: 10.1016/j.bbamcr.2006.08.044. Epub 2006 Sep 1. Biochim Biophys Acta. 2006. PMID: 17045662 Review.
-
Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane.PLoS One. 2009;4(4):e5090. doi: 10.1371/journal.pone.0005090. Epub 2009 Apr 7. PLoS One. 2009. PMID: 19352492 Free PMC article.
-
Regulation of peroxisomal lipid metabolism: the role of acyl-CoA and coenzyme A metabolizing enzymes.Biochimie. 2014 Mar;98:45-55. doi: 10.1016/j.biochi.2013.12.018. Epub 2014 Jan 2. Biochimie. 2014. PMID: 24389458 Review.
-
Peroxisomal fatty acid alpha- and beta-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases.Biochem Soc Trans. 2001 May;29(Pt 2):250-67. doi: 10.1042/0300-5127:0290250. Biochem Soc Trans. 2001. PMID: 11356164 Review.
-
Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism.Prog Lipid Res. 2008 Nov;47(6):405-21. doi: 10.1016/j.plipres.2008.05.001. Epub 2008 May 15. Prog Lipid Res. 2008. PMID: 18538142 Review.
Cited by
-
Metabolic Interplay between Peroxisomes and Other Subcellular Organelles Including Mitochondria and the Endoplasmic Reticulum.Front Cell Dev Biol. 2016 Jan 28;3:83. doi: 10.3389/fcell.2015.00083. eCollection 2015. Front Cell Dev Biol. 2016. PMID: 26858947 Free PMC article. Review.
-
Towards repurposing the yeast peroxisome for compartmentalizing heterologous metabolic pathways.Nat Commun. 2016 Mar 30;7:11152. doi: 10.1038/ncomms11152. Nat Commun. 2016. PMID: 27025684 Free PMC article.
-
Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis.Int J Mol Sci. 2019 Sep 5;20(18):4359. doi: 10.3390/ijms20184359. Int J Mol Sci. 2019. PMID: 31491949 Free PMC article.
-
Peroxisomal regulation of redox homeostasis and adipocyte metabolism.Redox Biol. 2019 Jun;24:101167. doi: 10.1016/j.redox.2019.101167. Epub 2019 Mar 14. Redox Biol. 2019. PMID: 30921635 Free PMC article. Review.
-
A Rewired NADPH-Dependent Redox Shuttle for Testing Peroxisomal Compartmentalization of Synthetic Metabolic Pathways in Komagataella phaffii.Microorganisms. 2024 Dec 30;13(1):46. doi: 10.3390/microorganisms13010046. Microorganisms. 2024. PMID: 39858813 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases